Our research focus are the molecular mechanisms underlying the structural organization of the presynaptic active zone and the molecular alterations involved in physiological and pathophysiological synaptic plasticity. In particular, we are interested in the following questions:
What are the fundamental mechanisms underlying the formation and maintenance of the active zone ultrastructure?
How does the CAZ contribute to mediating synaptic tenacity and synaptic stability?
What are the effects of physiological and pathophysiological activity on the composition and structure of the active zone?
Which signal transduction cascades mediate changes in the presynaptic release machinery in response to physiological and pathophysiological activity?
Role of the presynaptic release machinery during epileptogenesis.