German Center for Neurodegenerative Diseases (DZNE)
Phone: +49 228 43302-684
Our research aims at gaining a better functional understanding of disease-related changes of individual neuronal compartments such as single synapses on dendrites during behaviour. Even the smallest changes in the processing of synaptic signals can easily lead to a change in the output signal and thus disturb network function. A balanced interplay of excitatory neurons and inhibitory interneurons, under tight neuromodulatory brain-state dependent control, is required to direct the information flow through our memory systems. We use behavioural, computational, optogenetic, cellular imaging and multiple electrophysiological techniques to understand both the physiological circuits that underlie behaviour and the remodeling of memory-related neuronal networks in neurodegenerative diseases.