- This event has passed.
The dentate gyrus: A pattern separator driving formation of precise memories
June 8, 2020 at 11:00 am
Heinz Beck, Prof. Dr. Institute of Experimental Epileptology and Cognition Research, Life and Brain Center, University of Bonn
Host: Chi Wai Chan (Chi.Chan@caesar.de)
Discriminating minor changes in otherwise similar environments is essential for all mammals. This capability requires the ability to generate dissimilar neuronal representations from two overlapping input states representing two similar environments. Such an operation, termed pattern separation, has been ascribed to the hippocampal dentate gyrus in different species ranging from rodents to humans. The presentation will first address cellular and circuit mechanisms supporting pattern separation in the dentate gyrus. I will then describe a novel type of replay in the dentate gyrus that promotes the transformation of pattern-separated representations into precise memories.