Consortia

DFG Research Unit ‘Epileptogenesis of Genetic Epilepsies‘ (FOR 2715)
Coordinator: Prof. Dr. Holger Lerche
funding period: since 2017
This Research Group is examining how mutations interact with developmental processes to cause hyperexcitability and chronic epilepsy.

DFG Priority Programme ‘Functional Specialisations of Neuroglia as Critical Determinants of Brain Activity‘ (SPP 1757)
Coordinator: Prof. Dr. Frank Kirchhoff
funding period: since 2014

DFG Collaborative Research Center ‘Synaptic Micronetworks in Health and Disease‘ (SFB 1089)
Coordinator: Prof. Dr. Heinz Beck
funding period: since 2013
This CRC, inaugurated in October 2013, is focused on identifying fundamental rules that govern the dynamics of neuronal behavior at the network level, and the translation of neuronal network dynamics to mammalian and human behavior. In addition, the CRC is also committed to leveraging these approaches to understand the pathophysiology and therapy of common CNS diseases such as epilepsy and Alzheimer’s disease.

BMBF Competence Cluster ‘Diet-Body-Brain: From epidemiology to targeted approaches‘ (DietBB)
Coordinator: Prof. Dr. Ute Nöthlings
funding period: 2018-2021

BMBF Joint Project ‘Standardized systems for modeling late-onset neurological disorders and compound screening in 2D and 3D culture‘ (Neuro2D3)
Coordinator: Prof. Dr. Oliver Brüstle
funding period: 2017-2020

BMBF Joint Project ‘Validation of Connexin 43 as a target for disease-modifying anti-epileptogenic therapy‘ (CONNEXIN)
Coordinators: Prof. Dr. Christian Steinhäuser, Prof. Dr. Christa Müller
funding period: 2018-2019

ERA-NET NEURON Project ‘Deciphering hyperexcitable networks associated with neurodevelopmental lesions‘ (DeCipher)
Coordinator: Prof. Dr. Albert J. Becker
funding period: 2016-2019
This ERA-NET is examining the neuronal basis of epileptic seizure generation in models of developmental malformations using recent methodologies that allow controlled stimulation (by so-called advanced photostimulation and optogenetic techniques) and analyses of the functional consequences (by in-vivo electrophysiology and imaging) in the brains of living experimental animals.

JPND Project ‘Deciphering Interactions of Acquired Risk Factors and ApoE-mediated Pathways in Alzheimer’s Disease‘ (DACAPO-AD)
Coordinator: Prof. Dr. Gabor Petzold
funding period: 2016-2019

JPND Project ‘European Spinocerebellar Ataxia Type 3 / Machado-Joseph Disease Initiative‘ (ESMI)
Coordinator: Prof. Dr. Thomas Klockgether
funding period: 2016-2019
The central aim of ESMI is to bring together large cohorts of patients with standardized and quality-controlled assessment protocols. This will enable the discovery of new disease markers as well as clinical trials.

ERA-NET NEURON Project ‘Transition from acute to chronic neuroinflammation‘ (TracInflam)
Coordinator: Prof. Dr. Michael T. Heneka
funding period: 2015-2018

JPND Project ‘Innate Immune Activation in Neurodegenerative Disease‘ (InCure)
Coordinator: Prof. Dr. Michael T. Heneka
funding period: 2015-2018
The central aim of InCure is to study this innate immune activation by combining a systems biological approach and functional analysis of the three most frequent NDs: Alzheimer’s disease (AD), Parkinson’s disease (PD) and Fronto-TemporalDementia (FTD), all of which have been described to harbour an inflammatory disease component.