Collaborative Research Center ‘Synaptic Micronetworks in Health and Disease‘ (SFB 1089). Program Chair: Prof. H. Beck: This CRC, inaugurated in October 2013, is focused on identifying fundamental rules that govern the dynamics of neuronal behavior at the network level, and the translation of neuronal network dynamics to mammalian and human behavior. In addition, the CRC is also committed to leveraging these approaches to understand the pathophysiology and therapy of common CNS diseases such as epilepsy and Alzheimer’s disease.
ERA-NET Neuron „DeCipher“, Deciphering hyperexcitable networks associated with neurodevelopmental lesions, (DeCipher). Program Chair: Prof. A. Becker. This ERANET is examining the neuronal basis of epileptic seizure generation in models of developmental malformations using recent methodologies that allow controlled stimulation (by so-called advanced photostimulation and optogenetic techniques) and analyses of the functional consequences (by in-vivo electrophysiology and imaging) in the brains of living experimental animals.
DFG Forschergruppe „Epileptogenesis of Genetic Epilepsies“ Tübingen-Bonn, 2017-2021, Program Chair: Prof. H. Lerche (Tübingen). This Research Group is examining how mutations interact with developmental processes to cause hyperexcitability and chronic epilepsy.
BMBF: Neuro2D3 „Standardized systems for modeling late-onset neurological disorders and compound screening in 2D and 3D culture”, Coordinator: Prof. O. Brüstle.
ERA-NET Neuron „TracInflam“, Coordinator: Prof. M. Heneka.
JPND „InCure: Innate Immune Activation in Neurodegenerative Disease“, Coordinator: Prof. M. Heneka. The central aim of InCure is to study this innate immune activation by combining a systems biological approach and functional analysis of the three most frequent NDs: Alzheimer’s disease (AD), Parkinson’s disease (PD) and Fronto-TemporalDementia (FTD), all of which have been described to harbour an inflammatory disease component.
JPND „European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative (ESMI)”, Coordinator: Prof. T. Klockgether. The central aim of ESMI is to bring together large cohorts of patients with standardized and quality-controlled assessment protocols. This will enable the discovery of new disease markers as well as clinical trials.
JPND „Deciphering Interactions of Acquired Risk Factors and ApoE-mediated Pathways in Alzheimer’s Disease (DACAPO-AD)“, Coordinator: Prof. G. Petzold
BMBF: „Validation of Connexin 43 as a target for disease-modifying anti-epileptogenic therapy” (CONNEXIN), Koordinatoren: Prof. C. Steinhäuser, Prof. C. Müller (Pharmazie)
SPP1757 „Functional specializations of neuroglia“, Koordinator: Prof. F. Kirchhoff (Universität des Saarlandes),
BMBF Cluster Diet-Body-Brain, Coordinator: Prof. U. Nöthling.