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From Risk to Disorder: Decision-Making Dysfunctions in Psychosis
You are here:
From Risk to Disorder: Decision-Making Dysfunctions in Psychosis

Date: July 3, 2025 9:00 am

From Risk to Disorder: Decision-Making Dysfunctions in Psychosis

Speaker: PD Dr Franziska Knolle

Affiliation: Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Germany

Abstract
Alterations in decision-making are proposed to underlie several psychiatric disorders, such as psychosis.
Decision-making involves integrating information about future outcomes, such as their probability, reward
value, and effort cost. This process is shaped by the comparison between expected and actual outcomes,
commonly described in terms of prediction errors. In psychosis, aberrant prediction error signalling is thought
to bias belief formation toward unlikely or implausible outcomes, contributing to hallucinations and delusions.
Additionally, impairments in decision-making have been linked to negative symptoms, particularly motivational
deficits. I will present evidence for these alterations across different cohorts – from healthy adolescents with
psychotic-like experiences to individuals with chronic schizophrenia – using a range of tasks, including an
orthogonalised Go/No-Go task, the Two-Step task, and the Balloon Analogue Risk task combined with
computational modelling. These behavioural measures offer scalable, cost-effective tools for probing
mechanisms underlying psychotic symptoms.

Host: Ulrich Ettinger

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Venue:

Online: https://uni-bonn.zoom.us/j/67862809703?pwd=WHM3b3lIUFJYY2x0ekxLZUhxS3UvUT09
Meeting-ID: 678 6280 9703, Code: 193789

Contact:

Prof. Dr. Heinz Beck
Institute of Experimental Epileptology and Cognition Research
Life and Brain Center
University of Bonn Medical Center
Sigmund-Freud Str. 25
53127 Bonn

Contact:

Prof. Dr. Heinz Beck
Institute of Experimental Epileptology and Cognition Research
Life and Brain Center
University of Bonn Medical Center
Sigmund-Freud Str. 25
53127 Bonn

Contact:

Prof. Dr. Heinz Beck
Institute of Experimental Epileptology and Cognition Research
Life and Brain Center
University of Bonn Medical Center
Sigmund-Freud Str. 25
53127 Bonn