Can we prevent Alzheimer’s disease? A neuroimmunopathological perspective
Beyond Genes: Transcript-Resolved Biology in Neurodegeneration
Genetics, Viruses, and B cells: the Cause of Multiple Sclerosis
Interpretable Machine Learning for Neural System Identification
Building and rebuilding the binocular circuit
From Mice to Men and Back Again: Translating and Refining Treatment Strategies for Spinal Cord Injury
Targeting Protein Synthesis to Tackle Neurovirulence and Neurodegeneration
Too much of a good thing? How Rab39 Puts the Brakes on Synaptic Autophagy
Abstract: Presynaptic terminals can be located far from the neuronal cell body and are thought to independently regulate protein and organelle turnover. Autophagy is a critical process for maintaining proteostasis, and its synaptic dysregulation is associated with neurodegenerative diseases. We report a soma-centered mechanism that regulates autophagy-controlled protein turnover at distant presynaptic terminals in Drosophila. […]
Cell-type specific voltage imaging of neural spiking, oscillations, waves, and memory dynamics
Abstract: Fluorescent genetically encoded voltage-indicators report the membrane voltages of targeted cell-types. Recent advances in the development of these indicators have enabled optical voltage-imaging experiments capturing the spiking dynamics of up to 3 neuron classes at once in the brains of behaving mammals. We recently used this capability to uncover a new form of interaction between an […]