Our research efforts are focused on understanding the developmental mechanisms that shape the organization and function of the dopaminergic system. The dopaminergic system modulates several brain functions, including reward behavior, voluntary movement and cognitive processes. Its degeneration or dysfunction is implicated in common disorders of the nervous system, such as Parkinson’s disease, drug abuse disorders and schizophrenia. We investigate the mechanisms that direct the specification of distinct dopaminergic subtypes and the segregation of these subtypes into discrete neuronal clusters in the developing brain. We also explore how these developmental events determine the later connectivity and function of dopaminergic subtypes in the adult brain using a combination of developmental genetic approaches, genetic and viral tracing tools, various imaging methods (live-imaging, light-sheet imaging) and functional analysis.
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Prof. Dr. Heinz Beck Institute of Experimental Epileptology and Cognition Research Life and Brain Center University of Bonn Medical Center Sigmund-Freud Str. 25 53127 Bonn
Contact:
Prof. Dr. Heinz Beck Institute of Experimental Epileptology and Cognition Research Life and Brain Center University of Bonn Medical Center Sigmund-Freud Str. 25 53127 Bonn
Contact:
Prof. Dr. Heinz Beck Institute of Experimental Epileptology and Cognition Research Life and Brain Center University of Bonn Medical Center Sigmund-Freud Str. 25 53127 Bonn