Our research team is focused on deciphering the complex cell processes and molecular functions associated with brain deterioration caused by aging or disease, as well as its resulting effects. We subscribe to the theory, backed by numerous studies including ours, that damage to the brain from disease or aging sparks immune reactions. Over time, these reactions may become harmful, contributing not just to brain disorders linked with aging, but also to various psychiatric conditions.

In past research, we investigated how microglial cells (the brain’s immune cells) respond to lipid-rich, densely packed myelin debris, a byproduct of brain damage (Safaiyan et al., 2021 – Neuron). This debris stirs microglial activity, which brings CD8 T cells to the brain’s

white matter and triggers immune responses, causing a loss of white matter cells (Liu et al., 2021 – StarProtocols, Kaya et al., 2022 – Nature Neuroscience, Androvic et al., 2023 – Nature Comm).

Ultimately, our goal is to pinpoint the immune mechanisms that play a role in neurological and psychiatric disorders. We aim to further scientific understanding in these areas and aid in the development of diagnostic markers and treatments that can alter the course of these disorders.