We have a strong interest in understanding the mechanisms of central nervous system diseases and their effect on cognitive processes like learning and memory.

By using longitudinal structural and functional two-photon (2P) in vivo microscopy, neuronal manipulation techniques, behavioral tests and post mortem tissue characterization, we investigate neuronal ensembles and circuits involved in spatial and social cognition to decipher their role for behaviour and their impairments in the context of neurodegenerative and neuropsychiatric diseases. We further aim at unraveling the interactions of tumors of the central nervous system with their microenvironment, to identify routes of communication and thus help to develop novel treatment strategies.