We investigate extracellular vesicles (EVs) in neurodegenerative diseases. We are especially interested in EV mediated release of toxic, aggregated proteins, such as a-Synuclein, the determinants of their sorting into EVs and the contribution of their release to toxicity and propagation of disease pathology throughout the brain. We also explore physiological functions of EVs in the CNS, e.g. the effects of oligodendroglial EVs, using primary cell culture and mouse models. Furthermore, we are interested in oligodendroglial pathology in neurodegenerative diseases.
In addition, we focus on the detection of novel biomarkers from blood and cerebrospinal fluid (CSF) which may enable diagnosis and prognosis of neurodegenerative diseases in the prodromal or even preclinical stage.