Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes
New insights from the Epi25 Collaborative highlight the complex genetic architecture of epilepsy, identifying distinct ultra-rare genetic risk factors across various disorder subtypes through the largest whole-exome sequencing study conducted to date. Bonn, October 2024 – Identifying genetic risk factors for the highly heterogeneous disorder of epilepsy has long been a challenge for researchers. In […]
Region-specific spreading depolarization drives aberrant post-ictal behavior
Bonn researchers uncover how seizure-related focal spreading depolarization contributes to abnormal post-ictal behaviors in epilepsy. Bonn, October 12 – Understanding the neurobiological mechanisms underlying post-ictal symptoms in epilepsy such as confusion, aphasia, and unaware wandering, which are most frequently observed in temporal lobe epilepsy (TLE), has long been a challenge for researchers. A pivotal study […]
Single-neuron representations of odors in the human brain
Bonn researchers unveil how the brain encodes and interprets smells at the single-neuron level. October 9 – Our sense of smell is a vital aspect of how we interact with the world, guiding both animal and human behavior. However, the underlying neural processes of olfaction, particularly in humans, have remained largely mysterious. In a recent […]
Single-neuron Representation of Nonsymbolic and Symbolic Number Zero in the Human Medial Temporal Lobe
Bonn and Tübingen researchers uncover how the brain processes zero in both symbolic and nonsymbolic forms. October 2024 – Zero is a fundamental concept in mathematics, but how does the human brain represent it? A new study from researchers at the Universities of Bonn and Tübingen has provided groundbreaking insights into how neurons in the […]
Network State Changes in Sensory Thalamus Represent Learned Outcomes
Bonn researchers uncover how the auditory thalamus encodes reward outcomes, linking sensory processing to learning. Bonn, September 7 – Recent research led by Gründemann, group leader at DZNE and professor at the Medical Faculty of the University of Bonn, has revealed new insights into how the auditory thalamus, a sensory relay region in the brain, […]
Concept and location neurons in the human brain provide the ‘what’ and ‘where’ in memory formation
Bonn researchers explore the neural processes that help link different aspects of episodic memory. Bonn, September 10 – Our brains possess an incredible ability to encode and store memories, capturing the essence of our experiences by linking the ‘who/what,’ ‘where,’ and ‘when.’ In a recent study, Prof. Florian Mormann and his research team at the […]
Development of the Dopaminergic System: From Stem Cells to Circuits
The 2nd edition of the „Development of the Dopaminergic System: From Stem Cells to Circuits“ conference will take place from May 24-27, 2025 in Crete. The intricate development and function of dopamine neurons have become a focal point in neuroscience research, especially with the growing interest in generating dopaminergic neurons for cell replacement therapies in […]
Language improves learning in artificial networks
Bonn researchers get to the bottom of the social aspect ofcommunication for mental activity Bonn, September 05 – Across all species, critical skills are passed on from parents to offspring through communication. Researchers at the University Hospital Bonn (UKB) and the Researchers at the University of Bonn showed that effective communication relies on how both […]
Social network of synapses controls their actions
Researchers from Bonn and Japan clarify how neighboring synapses coordinate their response to plasticity signals Bonn, September 02 – Nerve cells in the brain receive thousands of synaptic signals via their „antenna“, the so-called dendritic branch.Permanent changes in synaptic strength correlate with changes in the size of dendritic spines. However, it was previously unclear how […]
How star-shaped cells increase flexible learning
Bonn, July 17- Bonn researchers solve the hidden mystery of the role of astrocytes for learning processes and memory in the brain Star-shaped glial cells, so-called astrocytes, are more than just a supporting cell of the brain. They are actively involved in learning processes and interact with the nerve cells. But what exactly is it […]