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Genetic and molecular signaturesof remembering and forgettingas a basis for innovative drug development
You are here:
Genetic and molecular signaturesof remembering and forgettingas a basis for innovative drug development

Date: September 1, 2022 4:30 pm

Genetic and molecular signatures of remembering and forgetting as a basis for innovative drug development

Speaker: Andreas Papassotiropoulos, Prof. MD

Large collaborative efforts have led to the identification of numerous wellvalidated genetic risk factors for common, complex diseases. Importantly, known drug targets for such complex diseases as type 2 diabetes, hyperlipidemia, multiple sclerosis, and psoriasis have turned up in the genomewide association studies (GWAS). Recent megaanalyses have also led to the robust identification of genetic risk factors for common neuropsychiatric disorders and to the notion that many of these factors are shared across diagnostic categories. Given the current evidence it is logical to assume that GWAS have the potential of translating into novel treatment targets for neuropsychiatric conditions. As will be shown and discussed, strategies for applying human genetics to drug discovery in neuroscience are being developed, have already provided promising repurposing candidates, and have led to the initiation of clinical trials. Importantly, the exploration of associations between a gene encoding a drug target and a number of phenotypes rather than a sole monolithic disease category will be crucial to capture a broader spectrum of relevant biological information and to provide drug repurposing opportunities. This aspect of genomeguided drug discovery is particularly relevant for neuropsychiatry and underscores the importance of using physiologically relevant cognitive, behavioral and emotional domains in addition to binary neuropsychiatric diagnoses.

Host: Monique M. B. Breteler, Prof.

ICAL-Link

Venue:

DZNE Lecture Hall or videoconference, using Google Chrome: https://call.lifesizecloud.com/15070818

Contact:

Prof. Dr. Heinz Beck
Institute of Experimental Epileptology and Cognition Research
Life and Brain Center
University of Bonn Medical Center
Sigmund-Freud Str. 25
53127 Bonn

Contact:

Prof. Dr. Heinz Beck
Institute of Experimental Epileptology and Cognition Research
Life and Brain Center
University of Bonn Medical Center
Sigmund-Freud Str. 25
53127 Bonn

Contact:

Prof. Dr. Heinz Beck
Institute of Experimental Epileptology and Cognition Research
Life and Brain Center
University of Bonn Medical Center
Sigmund-Freud Str. 25
53127 Bonn