Abstract
Identifying cognitive or biological markers to improve the identification of individuals with attention deficit
hyperactivity disorder (ADHD) is a current challenge for researchers. The endophenotype model offers the
possibility of integrating behavioral and genetic traits to trace the etiology of complex disorders such as ADHD.
Inhibitory oculomotor control meets the criteria of an endophenotype: it has been reported as a heritable trait,
it consistently discriminates between individuals with and without ADHD, and it overlaps with the
neurobiological basis of the disorder. In the city of Guadalajara, in Mexico, we conducted a study with triads,
where adolescents with and without ADHD and their biological parents were genotyped for DRD4 and DAT
genes. All participants performed pro- and anti-saccadic tests. In this presentation, we will review the main
cognitive and genetic findings, as well as the challenges we faced during the research.