Compensation of Epileptogenic Dynamics using Simulation-Based Inference from Spiking Microcircuit Models

Abstract: Spiking microcircuit models simulate neurons, action potentials, and synaptic transmission to reproduce healthy or pathological brain dynamics. These detailed models offer potential for personalized treatments of brain disorders, but identifying parameters that reproduce patient data in biologically detailed models remains challenging. We apply neural posterior estimation, a modern simulation-based inference method, to efficiently estimate […]

Neural computations underlying the regulation of motivated behavior

Abstract: As we interact with the world around us, we experience a constant stream of sensory inputs, and must generate a constant stream of behavioral actions. What makes brains more than simple input-output machines is their capacity to integrate sensory inputs with an animal’s own internal motivational state to produce behavior that is flexible and adaptive. […]